PPP1R13B antibody (AA 630-680)

Catalog No. ABIN7227388

The Rabbit Polyclonal anti-PPP1R13B antibody (ABIN7227388) specifically detects PPP1R13B in ELISA, IHC and IF. The antibody is reactive with Human and Mouse samples.

Quick Overview for PPP1R13B antibody (AA 630-680) (ABIN7227388)

Target: PPP1R13B (Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPP1R13B antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-PPP1R13B Antibody

Binding Specificity: AA 630-680

Purpose: Rabbit Anti-ASPP1 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of ASPP1

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human ASPP1 protein at AA range: 630-680

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-200,ELISA 1:10000-20000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for PPP1R13B

Target: PPP1R13B (Protein Phosphatase 1, Regulatory Subunit 13B (PPP1R13B))

Alternative Name: ASPP1

Background: Apoptosis-stimulating of p53 protein 1, Protein phosphatase 1 regulatory subunit 13BPPP1R13B encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. PPP1R13B (Protein Phosphatase 1 Regulatory Subunit 13B) is a Protein Coding gene. Among its related pathways are Activation of BH3-only proteins and TP53 Regulates Transcription of Cell Death Genes.

Gene ID: 23368

UniProt: Q96KQ4

Pathways: p53 Signaling