PTPN12 antibody

Catalog No. ABIN7230828

This Rabbit Polyclonal antibody specifically detects PTPN12 in WB and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for PTPN12 antibody (ABIN7230828)

Target: PTPN12 (Protein Tyrosine Phosphatase G1 (PTPN12))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTPN12 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-PTPN12 Antibody

Purpose: Rabbit Anti-PTN12 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of PTN12 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human PTN12 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for PTPN12

Target: PTPN12 (Protein Tyrosine Phosphatase G1 (PTPN12))

Alternative Name: PTN12

Background: Tyrosine-protein phosphatase non-receptor type 12, PTP-PEST, Protein-tyrosine phosphatase G1, PTPG1PTPN12 (Protein Tyrosine Phosphatase, Non-Receptor Type 12) is a Protein Coding gene. Diseases associated with PTPN12 include Colorectal Cancer and Colonic Benign Neoplasm. Among its related pathways are DNA Damage and Signaling by ERBB2. The protein encoded by PTPN12 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility.

Molecular Weight: 85kD

Gene ID: 5782

UniProt: Q05209