rala antibody (AA 170-250)

Catalog No. ABIN7230952

This Rabbit Polyclonal antibody specifically detects rala in WB and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for rala antibody (AA 170-250) (ABIN7230952)

Target: rala (Ras-related Protein Ral-A (rala))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This rala antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-rala Antibody

Binding Specificity: AA 170-250

Purpose: Rabbit Anti-RASL1 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of RASL1 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human RASL1 protein at AA range: 170-250

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for rala

Target: rala (Ras-related Protein Ral-A (rala))

Alternative Name: RASL1

Background: RasGAP-activating-like protein 1, RAS protein activator like 1, Ras GTPase-activating-like proteinThe protein encoded by RASAL1 (RAS Protein Activator Like 1) is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described.

Molecular Weight: 88kD

Gene ID: 8437

UniProt: O95294

Pathways: Neurotrophin Signaling Pathway, SARS-CoV-2 Protein Interactome