Serotonin Receptor 1E antibody (AA 70-150)

Catalog No. ABIN7217098

The Rabbit Polyclonal anti-Serotonin Receptor 1E antibody is suitable to detect Serotonin Receptor 1E in samples from Human. It has been validated for ELISA, IHC and IF.

Quick Overview for Serotonin Receptor 1E antibody (AA 70-150) (ABIN7217098)

Target: Serotonin Receptor 1E (HTR1E)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Serotonin Receptor 1E antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-Serotonin Receptor 1E Antibody

Binding Specificity: AA 70-150

Purpose: Rabbit Anti-SR-1E Polyclonal Antibody

Specificity: SR-1E Polyclonal Antibody detects endogenous levels of SR-1E protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human SR-1E at AA range: 70-150

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IF/ICC1:50-300,ELISA 1:2000-20000,IHC 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Serotonin Receptor 1E

Target: Serotonin Receptor 1E (HTR1E)

Alternative Name: SR-1E

Background: HTR1E, 5-hydroxytryptamine receptor 1E, 5-HT-1E, 5-HT1E, S31, Serotonin receptor 1EHTR1E (5-Hydroxytryptamine Receptor 1E) is a Protein Coding gene. Diseases associated with HTR1E include attention deficit-hyperactivity disorder. Among its related pathways are Signaling by GPCR and cAMP signaling pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and serotonin binding. An important paralog of this gene is HTR1F. G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Serotonin 5-ht1E receptors are primarily located in the frontal cortex, caudate putamen, claustrum, hippocampus, and amygdala. The human 5-ht1E receptor gene has been localized to chromosome 6 (6q14-q15), the receptor is closely related to the serotonin 5-HT1F receptor.

Molecular Weight: 42kD

Gene ID: 3354

UniProt: P28566

Pathways: JAK-STAT Signaling, cAMP Metabolic Process