SH3BP1 antibody (AA 170-250)

Catalog No. ABIN7227092

The Rabbit Polyclonal anti-SH3BP1 antibody (ABIN7227092) specifically detects SH3BP1 in WB and ELISA. The antibody is reactive with Human and Mouse samples.

Quick Overview for SH3BP1 antibody (AA 170-250) (ABIN7227092)

Target: SH3BP1 (SH3-Domain Binding Protein 1 (SH3BP1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SH3BP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-SH3BP1 Antibody

Binding Specificity: AA 170-250

Purpose: Rabbit Anti-3BP1 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of 3BP1 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human 3BP1 protein at AA range: 170-250

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for SH3BP1

Target: SH3BP1 (SH3-Domain Binding Protein 1 (SH3BP1))

Alternative Name: 3BP1

Background: SH3 domain-binding protein 1SH3BP1 encodes a member of the Rho GTPase activating protein (RhoGAP) family. The encoded protein regulates Rac signaling and plays a role in cytoskeletal dynamics, cell motility and epithelial junction formation. This protein's association with the exocyst complex, which tethers secretory vesicles to the plasma membrane, has been demonstrated to be important in cell motility. In a distinct complex, this protein has been shown to regulate epithelial junction formation and morphogenesis. By interacting with the Plexin-D1 cell surface receptor, this protein mediates changes in the cytoskeleton in response to semaphorin binding. This protein may promote metastasis in human liver cancer cells and tissues.

Molecular Weight: 77kD

Gene ID: 23616

UniProt: Q9Y3L3