Stanniocalcin 2 antibody (AA 170-250)

Catalog No. ABIN7231560

The Rabbit Polyclonal anti-Stanniocalcin 2 antibody (ABIN7231560) specifically detects Stanniocalcin 2 in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Stanniocalcin 2 antibody (AA 170-250) (ABIN7231560)

Target: Stanniocalcin 2 (STC2)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Stanniocalcin 2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Stanniocalcin 2 Antibody

Binding Specificity: AA 170-250

Purpose: Rabbit Anti-STC2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of STC2 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human STC2 protein at AA range: 170-250

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for Stanniocalcin 2

Target: Stanniocalcin 2 (STC2)

Alternative Name: STC2

Background: Stanniocalcin-related protein, STC-related protein, STCRPSTC2 encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of STC2 is induced by estrogen and altered in some breast cancers.

Molecular Weight: 33kD

Gene ID: 8614

UniProt: O76061

Pathways: Hormone Activity, ER-Nucleus Signaling, SARS-CoV-2 Protein Interactome