STEAP2 antibody (AA 400-480)

Catalog No. ABIN7209926

This Rabbit Polyclonal antibody specifically detects STEAP2 in IHC, ELISA, WB and IF. It exhibits reactivity toward Human and Mouse.

Quick Overview for STEAP2 antibody (AA 400-480) (ABIN7209926)

Target: STEAP2 (STEAP Family Member 2, Metalloreductase (STEAP2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STEAP2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-STEAP2 Antibody

Binding Specificity: AA 400-480

Purpose: Rabbit Anti-STEAP2 Polyclonal Antibody

Specificity: STEAP2 Polyclonal Antibody detects endogenous levels of STEAP2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the C-terminal region of human STEAP2 at AA range: 400-480

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC: 1:100-300,ELISA 1:20000,IF 1:100-300,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for STEAP2

Target: STEAP2 (STEAP Family Member 2, Metalloreductase (STEAP2))

Alternative Name: STEAP2

Background: STEAP2, PCANAP1, STAMP1, Metalloreductase STEAP2, Prostate cancer-associated protein 1, Protein up-regulated in metastatic prostate cancer, PUMPCn, Six-transmembrane epithelial antigen of prostate 2, SixTransMembrane protein of prostate 1STEAP2 is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Molecular Weight: 56 KD

Gene ID: 261729

UniProt: Q8NFT2

Pathways: Transition Metal Ion Homeostasis