SYN1 antibody (pSer553)

Catalog No. ABIN7226768

This Rabbit Polyclonal antibody specifically detects SYN1 in WB and ELISA. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for SYN1 antibody (pSer553) (ABIN7226768)

Target: SYN1 (Synapsin I (SYN1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SYN1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-SYN1 Antibody

Binding Specificity: pSer553

Purpose: Synapsin-1 (phospho Ser553) Polyclonal Antibody

Specificity: Phospho-Synapsin-1 (S553) Polyclonal Antibody detects endogenous levels of Synapsin-1 around the phosphorylation site of S553 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogen: Synthesized peptide derived from human Synapsin-1 Phospho-Ser553

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000). Not yet tested in other applications.

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for SYN1

Target: SYN1 (Synapsin I (SYN1))

Alternative Name: Synapsin-1

Background: Rabbit Anti-Synapsin-1 (phospho Ser553) Polyclonal Antibody,SYN1 (synapsin I) is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in SYN1 may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.,Synapsin-1

Molecular Weight: observerd band 75kDa

Gene ID: 6853

UniProt: P17600