TAL1 antibody

Catalog No. ABIN7224606

This Rabbit Polyclonal antibody specifically detects TAL1 in WB, ELISA, IHC and IF. It exhibits reactivity toward Human and Mouse.

Quick Overview for TAL1 antibody (ABIN7224606)

Target: TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TAL1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-TAL1 Antibody

Purpose: Rabbit Anti-TAL1 Polyclonal Antibody

Specificity: TAL1 Polyclonal Antibody detects endogenous levels of TAL1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human TAL1 around the non-phosphorylation site of S122

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,ELISA 1:20000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for TAL1

Target: TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))

Alternative Name: TAL1

Background: TAL1, BHLHA17, SCL, TCL5, T-cell acute lymphocytic leukemia protein 1, TAL-1, Class A basic helix-loop-helix protein 17, bHLHa17, Stem cell protein, T-cell leukemia/lymphoma protein 5The basic helix-loop-helix (bHLH) family of transcription factors play roles in a variety of developmental and adult biological settings. The basic (b) domain of bHLH transcription factors allows association with DNA, while the HLH domain facilitates the mono- and heterodimeric interactions required for efficient DNA binding. TAL1, also known as SCL, is a bHLH transcription factor that plays an essential role in the generation of embryonic hematopoietic stem cells , and is required for maturation of erythroid and megakaryocytic lineages in the adult. TAL1 interacts with Lim-domain containing proteins LMO2 and Ldb1, and has been found in complexes with these proteins as well as the hematopoietic transcription factor GATA-1. Both TAL1 and LMO2 have been associated with T-cell acute lymphoblastic leukemia (T-ALL). TAL1 activity is essential for both hematopoiesis and neurogenesis.

Molecular Weight: 45kD

Gene ID: 6886

UniProt: P17542

Pathways: Stem Cell Maintenance