TMPRSS3 antibody (AA 380-460)

Catalog No. ABIN7217340

This Rabbit Polyclonal antibody specifically detects TMPRSS3 in WB, ELISA, IHC and IF. It exhibits reactivity toward Human and Mouse.

Quick Overview for TMPRSS3 antibody (AA 380-460) (ABIN7217340)

Target: TMPRSS3 (Transmembrane Protease, Serine 3 (TMPRSS3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMPRSS3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-TMPRSS3 Antibody

Binding Specificity: AA 380-460

Purpose: Rabbit Anti-TMPRSS3 Polyclonal Antibody

Specificity: TMPRSS3 Polyclonal Antibody detects endogenous levels of TMPRSS3 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the C-terminal region of human TMPRSS3 at AA range: 380-460

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,IF 1:200-1:1000,ELISA 1:10000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for TMPRSS3

Target: TMPRSS3 (Transmembrane Protease, Serine 3 (TMPRSS3))

Alternative Name: TMPRSS3

Background: TMPRSS3, ECHOS1, TADG12, Transmembrane protease serine 3, Serine protease TADG-12, Tumor-associated differentially-expressed gene 12 proteinTMPRSS3 encodes transmembrane protease serine 3 that belongs to the serine protease family. The transmembrane protease serine 3 contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. TMPRSS3 was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described.

Molecular Weight: 49kD

Gene ID: 64699

UniProt: P57727

Pathways: Sensory Perception of Sound