Transportin 1 antibody

Catalog No. ABIN7231862

The Rabbit Polyclonal anti-Transportin 1 antibody has been validated for WB and ELISA. It is suitable to detect Transportin 1 in samples from Human and Mouse.

Quick Overview for Transportin 1 antibody (ABIN7231862)

Target: Transportin 1 (TNPO1)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Transportin 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Transportin 1 Antibody

Purpose: TNPO1 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of TNPO1 protein

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen

Immunogen: Synthesized peptide derived from part region of human TNPO1 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:5000-1:20000).

Comment:

Primary Antibody

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Target Details for Transportin 1

Target: Transportin 1 (TNPO1)

Alternative Name: TNPO1

Background: Rabbit Anti-TNPO1 Polyclonal Antibody,Transportin-1, Importin beta-2, Karyopherin beta-2, M9 region interaction protein, MIP,TNPO1 (Transportin 1) is a Protein Coding gene. Diseases associated with TNPO1 include Hiv-1 and Dementia, Frontotemporal. Among its related pathways are Development_TGF-beta receptor signaling and CDK-mediated phosphorylation and removal of Cdc6. TNPO1 encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of TNPO1 results in two transcript variants encoding different proteins.,TNPO1

Molecular Weight: observerd band 98kDa

Gene ID: 3842

UniProt: Q92973

Pathways: PI3K-Akt Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Cellular Glucan Metabolic Process, Protein targeting to Nucleus, CXCR4-mediated Signaling Events