TYK2 antibody

Catalog No. ABIN7217414

The Rabbit Polyclonal anti-TYK2 antibody (ABIN7217414) specifically detects TYK2 in WB, ELISA, IHC and IF. The antibody is reactive with Human, Mouse and Monkey samples.

Quick Overview for TYK2 antibody (ABIN7217414)

Target: TYK2 (Tyrosine Kinase 2 (TYK2))

Reactivity: Human, Mouse, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TYK2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-TYK2 Antibody

Purpose: Rabbit Anti-Tyk 2 Polyclonal Antibody

Specificity: Tyk 2 Polyclonal Antibody detects endogenous levels of Tyk 2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human Tyk 2 around the non-phosphorylation site of Y1054

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,IF 1:200-1:1000,ELISA 1:10000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for TYK2

Target: TYK2 (Tyrosine Kinase 2 (TYK2))

Alternative Name: Tyk 2

Background: TYK2, Non-receptor tyrosine-protein kinase TYK2TYK2 encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. Non-receptor tyrosine-protein kinase TYK2 associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.

Molecular Weight: 134kD

Gene ID: 7297

UniProt: P29597

Pathways: JAK-STAT Signaling, Hepatitis C