UBR2 antibody

Catalog No. ABIN7232020

This Rabbit Polyclonal antibody specifically detects UBR2 in WB and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for UBR2 antibody (ABIN7232020)

Target: UBR2 (Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBR2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-UBR2 Antibody

Purpose: Rabbit Anti-UBR2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of UBR2 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human UBR2 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for UBR2

Target: UBR2 (Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2))

Alternative Name: UBR2

Background: E3 ubiquitin-protein ligase UBR2, N-recognin-2, RING-type E3 ubiquitin transferase UBR2, Ubiquitin-protein ligase E3-alpha-2, Ubiquitin-protein ligase E3-alpha-IIUBR2 encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation. Alternative splicing results in multiple transcript variants. UBR2 (Ubiquitin Protein Ligase E3 Component N-Recognin 2) is a Protein Coding gene. Diseases associated with UBR2 include Johanson-Blizzard Syndrome and Rapadilino Syndrome. Among its related pathways are SMAD Signaling Network and Class I MHC mediated antigen processing and presentation.

Molecular Weight: 193kD

Gene ID: 23304

UniProt: Q8IWV8