UGDH antibody (AA 360-440)

Catalog No. ABIN7224864

The Rabbit Polyclonal anti-UGDH antibody (ABIN7224864) specifically detects UGDH in WB, ELISA, IHC and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for UGDH antibody (AA 360-440) (ABIN7224864)

Target: UGDH (UDP-Glucose 6-Dehydrogenase (UGDH))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UGDH antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-UGDH Antibody

Binding Specificity: AA 360-440

Purpose: Rabbit Anti-UDP-GlcDH Polyclonal Antibody

Specificity: UDP-GlcDH Polyclonal Antibody detects endogenous levels of UDP-GlcDH protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the C-terminal region of human UDP-GlcDH at AA range: 360-440

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,ELISA 1:10000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for UGDH

Target: UGDH (UDP-Glucose 6-Dehydrogenase (UGDH))

Alternative Name: UDP-GlcDH

Background: UGDH, UDP-glucose 6-dehydrogenase, UDP-Glc dehydrogenase, UDP-GlcDH, UDPGDHThe protein encoded by UGDH (UDP-glucose 6-dehydrogenase) converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of UGDH is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.

Molecular Weight: 55kD

Gene ID: 7358

UniProt: O60701

Pathways: Glycosaminoglycan Metabolic Process