Caspase 4 antibody (AA 91-105)

Catalog No. ABIN7232775

This anti-Caspase 4 antibody is a Rabbit Polyclonal antibody detecting Caspase 4 in WB, ELISA and IHC (p). Suitable for Human.

Quick Overview for Caspase 4 antibody (AA 91-105) (ABIN7232775)

Target: Caspase 4 (CASP4) (Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase 4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Caspase 4 Antibody

Binding Specificity: AA 91-105

Purpose: Anti-Caspase-13 Rabbit Polyclonal Antibody

Specificity: This antibody recognizes human, mouse, and rat caspase-13 (43 kDa).

Cross-Reactivity: Human, Mouse, Rat

Immunogen: Peptide corresponding to aa 91- 105 of human caspase-13 (accession no. O75601).

Isotype: IgG

Application Details

Application Notes: Immunoblotting: use at 1 μg/mL.
Immunohistochemistry: use at 10 μg/mL.
These are recommended concentrations.
Endusers should determine optimal concentrations for their applications.
Positive control: Whole cell lysate from HL60 cells.

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: Dilute in PBS or medium which is identical to that used in the assay system.

Concentration: Lot specific

Buffer: PBS, pH 7.4

Storage: -20 °C

Storage Comment: This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.

Target Details for Caspase 4

Target: Caspase 4 (CASP4) (Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))

Alternative Name: CASP13

Background: Caspase-13,Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.,Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain-containing adapter molecules and members of the caspase family of proteases. Caspase-13 or ERICE (Evolutionarily Related Interleukin-1 Converting Enzyme) was recently described. When activated by caspase-8, caspase-13 induces apoptosis. Caspase-13 is expressed in a variety of human tissues and cell lines.,CASP-13, EC 3.4.22.-, Evolutionary related interleukin-1-beta-converting enzyme, ERICE [Cleaved into: Caspase-13 subunit 1, Caspase-13 subunit 2]

Gene ID: 338039

NCBI Accession: NP_788811

UniProt: O75601

Pathways: Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity