APOB antibody

Catalog No. ABIN7265635

Product Details anti-APOB Antibody

Target: APOB (Apolipoprotein B (APOB))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This APOB antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: ApoB Rabbit mAb

Cross-Reactivity: Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human ApoB

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for APOB

Target: APOB (Apolipoprotein B (APOB))

Alternative Name: APOB (APOB Products)

Synonyms: FLDB antibody, LDLCQ4 antibody, Ac1-060 antibody, Apo B-100 antibody, ApoB-100 antibody, ApoB-48 antibody, AI315052 antibody, apob-100 antibody, apob-48 antibody, APOB-100 antibody, ApoB(100) antibody, APOB antibody, apolipoprotein B antibody, APOB antibody, Apob antibody

Background: This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq, Jul 2008],FLDB, LDLCQ4, apoB-100, apoB-48,Cancer,Cardiovascular,Cardiovascular diseases,Cardiovascular diseases_Heart disease,Endocrine & Metabolism,Heart,Lipid Metabolism,Lipid Metabolism_Cholesterol Metabolism,Lipids,Lipids_Lipoproteins/Apolipoproteins,Signal Transduction,APOB

Molecular Weight: 515kDa

Gene ID: 338

UniProt: P04114

Pathways: Lipid Metabolism