CDK12 antibody (AA 80-290)

Catalog No. ABIN7266230

The Rabbit Polyclonal anti-CDK12 antibody is suitable to detect CDK12 in samples from Human. It has been validated for WB and IHC.

Quick Overview for CDK12 antibody (AA 80-290) (ABIN7266230)

Target: CDK12 (CRKRS) (Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDK12 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-CDK12 Antibody

Binding Specificity: AA 80-290

Purpose: CDK12 Rabbit pAb

Sequence: SDTFSDDMAF KLDRRENDER RGSDRSDRLH KHRHHQHRRS RDLLKAKQTE KEKSQEVSSK SGSMKDRISG SSKRSNEETD DYGKAQVAKS SSKESRSSKL HKEKTRKERE LKSGHKDRSK SHRKRETPKS YKTVDSPKRR SRSPHRKWSD SSKQDDSPSG ASYGQDYDLS PSRSHTSSNY DSYKKSPGST SRRQSVSPPY KEPSAYQSST R

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 80-290 of human CDK12 (NP_057591.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CDK12

Target: CDK12 (CRKRS) (Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS))

Alternative Name: CDK12

Background: Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD of the large subunit of RNA polymerase II (POLR2A, thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.,CDK12,CRK7,CRKR,CRKRS,Cancer,Signal Transduction,Kinase,Tyrosine kinases,CDK12

Molecular Weight: 141kDa/163kDa/164kDa

Gene ID: 51755

UniProt: Q9NYV4