HIRA antibody

Catalog No. ABIN7267656

The Rabbit Monoclonal anti-HIRA antibody (ABIN7267656) specifically detects HIRA in WB. The antibody is reactive with Human samples.

Quick Overview for HIRA antibody (ABIN7267656)

Target: HIRA (HIR Histone Cell Cycle Regulation Defective Homolog A (HIRA))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This HIRA antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HIRA Antibody

Purpose: HIRA Rabbit mAb

Cross-Reactivity: Human

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human HIRA

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for HIRA

Target: HIRA (HIR Histone Cell Cycle Regulation Defective Homolog A (HIRA))

Alternative Name: HIRA

Background: This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008],DGCR1, TUP1, TUPLE1,Cell Biology & Developmental Biology,Chromatin Remodeling,Epigenetics & Nuclear Signaling,Germline Stem Cells,Stem Cells,HIRA

Molecular Weight: 112kDa

Gene ID: 7290

UniProt: P54198

Pathways: Chromatin Binding