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LAPTM4B antibody (AA 218-317)

LAPTM4B Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7268341
  • Target See all LAPTM4B Antibodies
    LAPTM4B (Lysosomal Protein Transmembrane 4 beta (LAPTM4B))
    Binding Specificity
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 218-317
    Reactivity
    • 13
    • 6
    • 6
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    Human
    Host
    • 13
    Rabbit
    Clonality
    • 13
    Polyclonal
    Conjugate
    • 9
    • 2
    • 1
    • 1
    This LAPTM4B antibody is un-conjugated
    Application
    • 9
    • 5
    • 4
    • 2
    • 1
    Western Blotting (WB)
    Purpose
    LAPTM4B Rabbit pAb
    Sequence
    NSIQEYIRQL PPNFPYRDDV MSVNPTCLVL IILLFISIIL TFKGYLISCV WNCYRYINGR NSSDVLVYVT SNDTTVLLPP YDDATVNGAA KEPPPPYVSA
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 218-317 of human LAPTM4B (NP_060877.3).
    Isotype
    IgG
    Top Product
    Discover our top product LAPTM4B Primary Antibody
  • Application Notes
    WB,1:500 - 1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    LAPTM4B (Lysosomal Protein Transmembrane 4 beta (LAPTM4B))
    Alternative Name
    LAPTM4B (LAPTM4B Products)
    Synonyms
    LAPTM4beta antibody, LC27 antibody, C330023P13Rik antibody, lysosomal protein transmembrane 4 beta antibody, lysosomal-associated protein transmembrane 4B antibody, LAPTM4B antibody, Laptm4b antibody
    Background
    Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter to the lysosome, promoting entry of leucine and other essential amino acid (EAA into the lysosome, stimulating activation of proton-transporting vacuolar (V-ATPase protein pump (V-ATPase and hence mTORC1 activation. Plays a role as negative regulator of TGFB1 production in regulatory T cells. Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways.,LAPTM4B,LAPTM4beta,LC27,Cancer,Tumor biomarkers,LAPTM4B
    Molecular Weight
    25kDa/35kDa/41kDa
    Gene ID
    55353
    UniProt
    Q86VI4
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