MEK2 antibody

Catalog No. ABIN7268639

The Rabbit Monoclonal anti-MEK2 antibody has been validated for WB. It is suitable to detect MEK2 in samples from Human.

Quick Overview for MEK2 antibody (ABIN7268639)

Target: MEK2 (MAP2K2) (Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MEK2 antibody is un-conjugated

Application: Western Blotting (WB)

Grade: KO Validated

Product Details anti-MEK2 Antibody

Purpose: [KO Validated] MEK2 Rabbit mAb

Cross-Reactivity: Human, Mouse

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human MEK2

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MEK2

Target: MEK2 (MAP2K2) (Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2))

Alternative Name: MAP2K2

Background: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008],CFC4,MAPKK2,MEK2,MKK2,PRKMK2,MAP2K2,Angiogenesis,B Cell Receptor Signaling Pathway,Cancer,Cardiovascular,Cell Biology & Developmental Biology,Cytoskeleton,Cytoskeleton_Actins,Endocrine & Metabolism,ErbB-HER Signaling Pathway,ESC Pluripotency and Differentiation,G protein signaling,G protein signaling_G-Protein-Coupled Receptors Signaling to MAPK/Erk,IL-6 Receptor Signaling Pathway,Immunology & Inflammation,Insulin Receptor Signaling Pathway,Kinase,Kinase_Serine/threonine kinases,Kinase_Tyrosine kinases,MAPK-Erk Signaling Pathway,Neurodegenerative Diseases,Neuroscience,Signal Transduction,T Cell Receptor Signaling Pathway,Warburg Effect,MAP2K2

Molecular Weight: 44kDa

Gene ID: 5605

UniProt: P36507

Pathways: MAPK Signaling, RTK Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling