Neuregulin 3 antibody

Catalog No. ABIN7268859

This anti-Neuregulin 3 antibody is a Rabbit Monoclonal antibody detecting Neuregulin 3 in WB. Suitable for Human.

Quick Overview for Neuregulin 3 antibody (ABIN7268859)

Target: Neuregulin 3 (NRG3)

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Neuregulin 3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Neuregulin 3 Antibody

Purpose: Neuregulin-3 (NRG3) Rabbit mAb

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human Neuregulin-3 (Neuregulin-3 (NRG3))

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Neuregulin 3

Target: Neuregulin 3 (NRG3)

Alternative Name: NRG3

Background: This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009],HRG3, pro-NRG3,Cancer,ErbB-HER Signaling Pathway,Neuroscience,Signal Transduction,NRG3

Molecular Weight: 56kDa

Gene ID: 10718

UniProt: P56975

Pathways: RTK Signaling