NAIP antibody (AA 750-850)

Catalog No. ABIN7268932

This Rabbit Polyclonal antibody specifically detects NAIP in WB. It exhibits reactivity toward Human.

Quick Overview for NAIP antibody (AA 750-850) (ABIN7268932)

Target: NAIP (NLR Family, Apoptosis Inhibitory Protein (NAIP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NAIP antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-NAIP Antibody

Binding Specificity: AA 750-850

Purpose: NAIP Rabbit pAb

Sequence: LLRSIHFPIR GNKTSPRAHF SVLETCFDKS QVPTIDQDYA SAFEPMNEWE RNLAEKEDNV KSYMDMQRRA SPDLSTGYWK LSPKQYKIPC LEVDVNDIDV V

Cross-Reactivity: Rat

Characteristics: Polyclonal Antibodies

Purification: Affinity purification

Immunogen: A synthetic peptide corresponding to a sequence within amino acids 750-850 of human NAIP (NP_075043.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for NAIP

Target: NAIP (NLR Family, Apoptosis Inhibitory Protein (NAIP))

Alternative Name: NAIP

Background: This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length, additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternative splicing and the use of alternative promoters results in multiple transcript variants.,NAIP,BIRC1,NLRB1,psiNAIP,Cell Biology & Developmental Biology,Apoptosis,NAIP

Gene ID: 4671

UniProt: Q13075

Pathways: Apoptosis, Inflammasome