PSMC5 antibody

Catalog No. ABIN7269585

This anti-PSMC5 antibody is a Rabbit Monoclonal antibody detecting PSMC5 in WB and IF. Suitable for Human.

Quick Overview for PSMC5 antibody (ABIN7269585)

Target: PSMC5 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 5 (PSMC5))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PSMC5 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-PSMC5 Antibody

Purpose: PSMC5 Rabbit mAb

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: Recombinant protein of Human PSMC5.

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PSMC5

Target: PSMC5 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 5 (PSMC5))

Alternative Name: PSMC5

Background: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene.,PSMC5,S8,SUG-1,SUG1,TBP10,TRIP1,p45,p45/SUG,ATPase 5,Cell Biology & Developmental Biology,Ubiquitin,PSMC5

Molecular Weight: 44kDa/45kDa

Gene ID: 5705

UniProt: P62195

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway