Tuberin antibody

Catalog No. ABIN7271027

The Rabbit Monoclonal anti-Tuberin antibody has been validated for WB and IP. It is suitable to detect Tuberin in samples from Human.

Quick Overview for Tuberin antibody (ABIN7271027)

Target: Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Tuberin antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-Tuberin Antibody

Purpose: TSC2 Rabbit mAb

Cross-Reactivity: Human

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human Tuberin.

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IP,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Tuberin

Target: Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

Alternative Name: TSC2

Background: Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],LAM,PPP1R160,TSC4,TSC2,Tuberin,tuberin,AMPK Signaling Pathway,Apoptosis,Autophagy,Autophagy_Regulator,Cancer,Cell Biology & Developmental Biology,Cell Cycle,Cell Cycle_Cell cycle inhibitors,Endocrine & Metabolism,Endocrine and metabolic diseases,Endocrine and metabolic diseases_Obesity,Epigenetics & Nuclear Signaling,G protein signaling,Immunology & Inflammation,Insulin Receptor Signaling Pathway,MAPK-Erk Signaling Pathway,mTOR Signaling Pathway,PI3K-Akt Signaling Pathway,PI3K-Akt Signaling Pathway_Akt downstream targets,Protein phosphorylation,Signal Transduction,Translation Control,Translational Control_Regulation of eIF4 and p70 S6 Kinase,Tumor suppressors,TSC2

Molecular Weight: 200kDa

Gene ID: 7249

UniProt: P49815

Pathways: RTK Signaling, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus