CD21 antibody

Catalog No. ABIN7271881

This Mouse Monoclonal antibody specifically detects CD21 in FACS. It exhibits reactivity toward Human.

Quick Overview for CD21 antibody (ABIN7271881)

Target: CD21 (CR2) (Complement Component (3d/Epstein Barr Virus) Receptor 2 (CR2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD21 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Grade: GMP Grade

Clone: HB5

Product Details anti-CD21 Antibody

Purpose: CD21 Unconjugated Antibody

Characteristics: The mouse monoclonal antibody produced by clone HB5 binds to complement receptor 2 (CR2), known as CD21, a 145 kDa glycoprotein of the complement control protein family. It is a receptor for the complement components C3d and C3g and, under pathological circumstances, for the Epstein-Barr virus (EBV). As complement breakdown fragments remain bound to the agent initiating the complement activation in the first place, CD21 plays an important role in the uptake of immunocomplexes. In addition, it plays a role in B cell development and activation as well as memory B cell survival. Thus, it is a key component in developing and maintaining humoral immune response to T-dependent antigens. CD21 associates with CD19, CD81 and the B cell receptor. The cell surface marker CD21 is expressed on mature B cells and follicular dendritic cells. It is used as a cell marker for the phenotyping of leukemias.

Purification: Purified

Purity: >95 %

Immunogen: Human complement receptor 2 (CR2)

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS pH 7.2, 0.1 % (w/v) BSA, 0.09 % (w/v) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for CD21

Target: CD21 (CR2) (Complement Component (3d/Epstein Barr Virus) Receptor 2 (CR2))

Alternative Name: CD21

Gene ID: 1380

UniProt: P20023

Pathways: Complement System