Bcl-2 antibody (AA 41-54)

Catalog No. ABIN7272015

This anti-Bcl-2 antibody is a Mouse Monoclonal antibody detecting Bcl-2 in FACS. Suitable for Human.

Quick Overview for Bcl-2 antibody (AA 41-54) (ABIN7272015)

Target: Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Bcl-2 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Grade: GMP Grade

Clone: 1E2

Product Details anti-Bcl-2 Antibody

Binding Specificity: AA 41-54

Purpose: BCL-2 Unconjugated Antibody

Characteristics: The clone 100, a mouse monoclonal antibody, recognizes a 239 amino acid ~25 kDa human apoptosis regulator oncoprotein known as Bcl-2. It is an intracellular, integral membrane protein containing up to 4 Bcl-2 homology (BH) motifs which are found primarily in the nuclear envelope, endoplasmic reticulum and outer mitochondrial membrane. Bcl-2 is a conserved anti-apoptotic protein and plays important roles in the management of normal immunity. Nonrandom translocations with breakpoint at band q21 on chromosome 18 may cause bcl-2 gene deregulation and contribute to neoplastic transformation in human lymphomas.

Purification: Purified

Purity: >95 %

Immunogen: Human BCL-2 synthetic peptide aa. 41-54

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS pH 7.2, 0.1 % (w/v) BSA, 0.09 % (w/v) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for Bcl-2

Target: Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Alternative Name: BCL-2

Gene ID: 596

UniProt: P10415

Pathways: MAPK Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling