NFATC1 antibody

Catalog No. ABIN7384107

The Rabbit Polyclonal anti-NFATC1 antibody is suitable to detect NFATC1 in samples from Human, Mouse and Rat. It has been validated for WB and IHC.

Quick Overview for NFATC1 antibody (ABIN7384107)

Target: NFATC1 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1 (NFATC1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NFATC1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-NFATC1 Antibody

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human NFAT2 (NP_765978.1).

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:3000 IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for NFATC1

Target: NFATC1 (Nuclear Factor of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 1 (NFATC1))

Alternative Name: NFAT2

Background: NF-ATC,NF-ATc1.2,NFAT2,NFATc,NFATC1,The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.

Molecular Weight:

Observed_MW: 78 kDa

Calculated_MW: 38 kDa/74- 88 kDa/100-101 kDa

Gene ID: 4772

UniProt: O95644

Pathways: RTK Signaling, WNT Signaling, Fc-epsilon Receptor Signaling Pathway