SQSTM1 antibody

Catalog No. ABIN7384397

This Rabbit Monoclonal antibody specifically detects SQSTM1 in WB. It exhibits reactivity toward Human.

Quick Overview for SQSTM1 antibody (ABIN7384397)

Target: SQSTM1 (Sequestosome 1 (SQSTM1))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This SQSTM1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: R08-4H8

Product Details anti-SQSTM1 Antibody

Purification: Affinity Purified

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:1000

Restrictions: For Research Use only

Handling

Concentration: 300 μg/mL

Buffer: 50 mM Tris-Glycine( pH 7.4), 0.15M NaCl, 40 % Glycerol, 0.01 % Sodium azide and 0.05 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SQSTM1

Target: SQSTM1 (Sequestosome 1 (SQSTM1))

Alternative Name: SQSTM1/p62

Background: A170,DMRV,EBI 3 associated protein of 60 kDa,EBI 3 associated protein p60,EBI3 associated protein of 60 kDa,EBI3 associated protein p60,EBI3-associated protein of 60 kDa,EBIAP,FTDALS3,MGC127197,ORCA,OSF-6,Osi,OSIL,Oxidative stress induced like,p60,p62,p62B,Paget disease of bone 3,PDB 3,PDB3,Phosphotyrosine independent ligand for the Lck SH2 domain of 62 kDa,Phosphotyrosine independent ligand for the Lck SH2 domain p62,Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa,PKC-zeta-interacting protein,Protein kinase C-zeta-interacting protein,Sequestosome 1,Sequestosome-1,SQSTM 1,SQSTM,Sqstm1,STAP,STONE14,Ubiquitin binding protein p62,Ubiquitin-binding protein p62,ZIP 3,ZIP,ZIP3,Sequestosome 1 (SQSTM1/p62) is a multifunctional adaptor protein implicated in selective autophagy,cell signaling pathways,and tumorigenesis. p62 has been implicated in shuttling ubiquitinated and sometimes aggregated proteins for autophagic degradation. As a autophagy-specific substrate,p62 is degraded during the autophagic process,which makes intracellular level of p62 as a marker for autophagy flux. p62 is at the cross-roads of several signaling pathways including Ras/ Raf/ MAPK and NFκB and plays important role in cancer. p62 is a component of inclusion bodies/ protein aggregates found in human diseases,including Huntington's disease,Alzheimer's disease,Parkinson's disease in the brain,and nephropathic cystinosis in kidney (22074114,22860231,22714671). The molecular weight of p62 is predicted as 48/ 38 kDa,while western blot analyses using this antibody demonstrate the major band around 60-62 kDa in various tissues.

Molecular Weight:

Observed_MW: 62kDa

Calculated_MW: 48kDa

Gene ID: 8878

UniProt: Q13501

Pathways: NF-kappaB Signaling, Neurotrophin Signaling Pathway, Autophagy