YTHDF1 antibody

Catalog No. ABIN7384402

Product Details anti-YTHDF1 Antibody

Target: YTHDF1 (YTH Domain Family, Member 1 (YTHDF1))

Reactivity: Human, Hamster

Host: Rabbit

Clonality: Monoclonal

Conjugate: This YTHDF1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Affinity Purified

Clone: R05-2E7

Isotype: IgG

Application Details

Application Notes: WB 1:1000-1:2000

Restrictions: For Research Use only

Handling

Concentration: 300 μg/mL

Buffer: 50 mM Tris-Glycine( pH 7.4), 0.15M NaCl, 40 % Glycerol, 0.01 % Sodium azide and 0.05 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for YTHDF1

Target: YTHDF1 (YTH Domain Family, Member 1 (YTHDF1))

Alternative Name: YTHDF1 (YTHDF1 Products)

Synonyms: fb49c02 antibody, zgc:55657 antibody, wu:fb49c02 antibody, wu:fi19h06 antibody, wu:fj87f09 antibody, wu:fp06c11 antibody, MGC75606 antibody, MGC68505 antibody, 2210410K23Rik antibody, 8030473O16 antibody, C20orf21 antibody, YTH N(6)-methyladenosine RNA binding protein 1 antibody, YTH N(6)-methyladenosine RNA binding protein 1 L homeolog antibody, YTH N6-methyladenosine RNA binding protein 1 antibody, YTH domain family 1 antibody, ythdf1 antibody, ythdf1.L antibody, YTHDF1 antibody, Ythdf1 antibody

Background: C20orf21,DF1,YTHDF1, also named as YTH domain-containing family protein 1 or C20orf21, is a 559 amino acid protein, which localizes in the cytoplasm. YTHDF1 specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and promotes mRNA translation efficiency. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. YTHDF1 acts as a regulator of mRNA translation efficiency: promotes ribosome loading to m6A-containing mRNAs and interacts with translation initiation factors eIF3 (EIF3A or EIF3B) to facilitate translation initiation. YTHDF1 exists two isoform and calculated molecular weight of isoforms are 61 kDa and 21 kDa.

Molecular Weight:

Observed_MW: 61kDa

Calculated_MW: 61kDa

Gene ID: 54915

UniProt: P59326