CSTF2T antibody (AA 566-616)
Quick Overview for CSTF2T antibody (AA 566-616) (ABIN7448495)
Target
See all CSTF2T AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- AA 566-616
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Purpose
- Rabbit anti-CSTF2T/TauCSTF64 IHC Antibody, Affinity Purified
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Predicted Reactivity
- Mouse,Rat,Dog,Horse,Rabbit,Guinea pig_10141,Pig,Panda,Orangutan,Gorilla,Chimpanzee,African elephant,West Indian ocean coelacanth,White-tufted-ear marmoset,Soybean,Chinese hamster,Small-eared galago,Naked mole rat,Thirteen-lined ground squirrel,Northern white-cheeked gibbon
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Purification
- Affinity Purified
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Immunogen
- Between AA 566 and 616
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Isotype
- IgG
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Application Notes
- 1:100 - 1:500
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Restrictions
- For Research Use only
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Concentration
- 250 μg/mL
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Buffer
- Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide
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Preservative
- Sodium azide
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Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Storage
- 4 °C
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Expiry Date
- 12 months
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- CSTF2T (Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 2, 64kDa, tau Variant (CSTF2T))
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Alternative Name
- CSTF2T/TauCSTF64
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Background
- Background: CSTF2T, also known as tauCSTF-64, is a paralog of CstF-64, a component of the cleavage stimulation factor (CstF) that processes 3'-end formation and polyadenylation of mRNAs. The human CSTF2T/TauCSTF64 gene is located at 10q22-23, a site associated with neurological problems and male infertility. CSTF2T is expressed in all tissues and throughout meiosis in male germ cells. CstF-64 is also expressed ubiquitously, however because it is located on the X chromosome, its expression is temporarily silenced in germ cells by meiotic sex chromosome inactivation. During this inactivation, it is hypothesized that CSTF2T/TauCSTF64 can compensate for the loss of CstfF-64 expression. Recently, targeted disruption of CSTF2T/TauCSTF64 in mice has been shown to cause aberrant spermatogenesis and infertility providing more evidence for its importance in spermatogenesis.
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Gene ID
- 23283
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NCBI Accession
- NP_056050
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UniProt
- Q9H0L4
Target
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