DDB1 antibody (C-Term)

Catalog No. ABIN7448511

The Rabbit Polyclonal anti-DDB1 antibody (ABIN7448511) specifically detects DDB1 in IHC. The antibody is reactive with Human and Mouse samples.

Quick Overview for DDB1 antibody (C-Term) (ABIN7448511)

Target: DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DDB1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-DDB1 Antibody

Binding Specificity: C-Term

Purpose: Rabbit anti-DDB1 IHC Antibody, Affinity Purified

Predicted Reactivity: Rat,X. laevis,X. tropicalis,Bovine,Dog,Horse,Rabbit,Guinea pig_10141,Pig,Panda,Orangutan,Monkey,Gorilla,Chimpanzee,Crab-eating macaque,Chinese hamster,Small-eared galago,Gray short-tailed opossum,Green monkey,Thirteen-lined ground squirrel,Northern white-cheeked gibbon,Naked mole rat,African elephant,White-tufted-ear marmoset,Tasmanian devil,Little brown bat

Purification: Affinity Purified

Immunogen: Between AA 1100 and C-term

Isotype: IgG

Application Details

Application Notes: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for DDB1

Target: DDB1 (Damage Specific DNA Binding Protein 1 (DDB1))

Alternative Name: DDB1

Background: Background: DDB1 (DNA Damage Binding Protein 1) is a subunit of the DNA damage-binding protein complex (DDB) involved in DNA repair. As part of a complex with Cul4-based ubiquitin ligase, Cul4-Ddb1 can directly modify chromatin through the ubiquitination of histones as well as ubiquitinate other chromatin bound factors. A deficiency in Cul4-Ddb1 ubiquitin ligase has been associated with xeroderma pigmentosum, a heritable disease characterized by defects in nucleotide excision repair and skin cancer development.

Gene ID: 1642

UniProt: Q16531, Q13289

Pathways: DNA Damage Repair