PRKDC antibody (AA 2100-2150)

Catalog No. ABIN7448533

This Rabbit Polyclonal antibody specifically detects PRKDC in IHC. It exhibits reactivity toward Human.

Quick Overview for PRKDC antibody (AA 2100-2150) (ABIN7448533)

Target: PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRKDC antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-PRKDC Antibody

Binding Specificity: AA 2100-2150

Purpose: Rabbit anti-DNA-PKcs IHC Antibody, Affinity Purified

Predicted Reactivity: Monkey,Crab-eating macaque,Northern white-cheeked gibbon

Purification: Affinity Purified

Immunogen: Between AA 2100 and 2150

Isotype: IgG

Application Details

Application Notes: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for PRKDC

Target: PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide (PRKDC))

Alternative Name: DNA-PKcs

Background: Background: DNA-PKcs is the catalytic subunit of a DNA-dependent serine-threonine protein kinase (DNA-PK). DNA-PK is a heterotrimer comprised of DNA-PKcs and the Ku709/Ku86 dimer. DNA-PK is involved in DNA damage repair and V(D)J recombination. DNA-PK phosphorylates Artemis, a protein required for nonhomologous end-joining and is necessary for the loading of Artemis on damaged DNA.

Gene ID: 5591

NCBI Accession: NP_008835

UniProt: P78527

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response