MED12 antibody (C-Term)

Catalog No. ABIN7448660

The Rabbit Polyclonal anti-MED12 antibody has been validated for IHC. It is suitable to detect MED12 in samples from Human and Mouse.

Quick Overview for MED12 antibody (C-Term) (ABIN7448660)

Target: MED12 (Mediator Complex Subunit 12 (MED12))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MED12 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-MED12 Antibody

Binding Specificity: C-Term

Purpose: Rabbit anti-MED12 IHC Antibody, Affinity Purified

Predicted Reactivity: Rat,Bovine,Dog,Pig,Panda,Orangutan,Monkey,Chimpanzee,Bornean orangutan,Crab-eating macaque,Thirteen-lined ground squirrel,Small-eared galago,Naked mole rat,White-tufted-ear marmoset,Northern white-cheeked gibbon,Little brown bat

Purification: Affinity Purified

Immunogen: Between AA 2150 and C-term

Isotype: IgG

Application Details

Application Notes: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for MED12

Target: MED12 (Mediator Complex Subunit 12 (MED12))

Alternative Name: MED12

Background: Background: MED12 is a component of the multisubunit mediator complex that functions as an interface between gene-specific transcription factors and the RNA Pol II/general transcription factor machinery. The mediator complex was first identified as a coactivator of the thyroid hormone receptor and has since been observed to function as a coactivator of a variety of transcription factors. In this context, MED12 interaction with beta-catenin has been shown to be required for Wnt-signaling dependent transcription.

Gene ID: 9968

NCBI Accession: NP_005111

UniProt: Q93074

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Stem Cell Maintenance, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha, Tube Formation