MSH2 antibody (C-Term)

Catalog No. ABIN7448673

This anti-MSH2 antibody is a Rabbit Polyclonal antibody detecting MSH2 in IHC. Suitable for Human and Mouse.

Quick Overview for MSH2 antibody (C-Term) (ABIN7448673)

Target: MSH2 (Mismatch Repair Protein 2 (MSH2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MSH2 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-MSH2 Antibody

Binding Specificity: C-Term

Purpose: Rabbit anti-MSH2 IHC Antibody, Affinity Purified

Predicted Reactivity: Guinea pig_10141,Pig,Panda,Orangutan,Monkey,Gorilla,Green monkey,Northern white-cheeked gibbon,White-tufted-ear marmoset,Naked mole rat,Ferret,Crab-eating macaque

Purification: Affinity Purified

Immunogen: Between AA 875 and C-term

Isotype: IgG

Application Details

Application Notes: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for MSH2

Target: MSH2 (Mismatch Repair Protein 2 (MSH2))

Alternative Name: MSH2

Background: Background: MSH2 is an integral component of the DNA mismatch repair (MMR) system that functions to recognize aberrant structures and signals for the repair of single base mismatches or loops in replicated DNA. MSH2 has also been demonstrated to function as an anti-recombinase and may play a role in negatively regulating DNA repair. MSH2 can heterodimerize with MSH3 or MSH6. Mutations in MSH2 are linked to hereditary nonpolyposis colon cancer (HNPCC).

Gene ID: 4436

NCBI Accession: NP_000242

UniProt: P43246

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response