PML antibody (AA 375-425)

Catalog No. ABIN7448728

This Rabbit Polyclonal antibody specifically detects PML in IHC. It exhibits reactivity toward Human.

Quick Overview for PML antibody (AA 375-425) (ABIN7448728)

Target: PML (Promyelocytic Leukemia (PML))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PML antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-PML Antibody

Binding Specificity: AA 375-425

Purpose: Rabbit anti-PML IHC Antibody, Affinity Purified

Predicted Reactivity: Orangutan,Gorilla,Chimpanzee,Bornean orangutan,White-tufted-ear marmoset,Pygmy chimpanzee,Primates

Purification: Affinity Purified

Immunogen: Between AA 375 and 425

Isotype: IgG

Application Details

Application Notes: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 100 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for PML

Target: PML (Promyelocytic Leukemia (PML))

Alternative Name: PML

Background: Background: PML is a member of RBCC/TRIM family of proteins that possess a RING finger domain, B-box, and coiled-coil domain. PML is a multifunctional protein involved in activities such as tumor growth suppression, hematopoietic differentiation, gene transcription, apoptotic induction, and viral immunity. PML is often involved in chromosomal translocations with the retinoic acid receptor alpha gene. PML-retinoic acid receptor translocations are associated with acute promyelocytic leukemia.

Gene ID: 5371

NCBI Accession: NP_150241

UniProt: P29590

Pathways: p53 Signaling, Retinoic Acid Receptor Signaling Pathway, Maintenance of Protein Location, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus