BRCA1 antibody (AA 700-750)

Catalog No. ABIN7448934

This anti-BRCA1 antibody is a Rabbit Polyclonal antibody detecting BRCA1 in IHC and IF (p). Suitable for Human.

Quick Overview for BRCA1 antibody (AA 700-750) (ABIN7448934)

Target: BRCA1 (Breast Cancer 1 (BRCA1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BRCA1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-BRCA1 Antibody

Binding Specificity: AA 700-750

Purpose: Rabbit anti-BRCA1 IHC Antibody, Affinity Purified

Predicted Reactivity: Orangutan,Gorilla,Chimpanzee,Northern white-cheeked gibbon,Brown-headed spider monkey,Bornean orangutan,Long-haired spider monkey,Agile gibbon

Purification: Affinity Purified

Immunogen: Between AA 700 and 750

Isotype: IgG

Application Details

Application Notes:

IHC-IF: 1:50 - 1:500

IHC: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for BRCA1

Target: BRCA1 (Breast Cancer 1 (BRCA1))

Alternative Name: BRCA1

Background: Background: BRCA1 was identified as a gene with germline mutations that predisposes women to breast and ovarian cancer. The BRCA1 tumor suppressor is a large protein that has been demonstrated to interact with a multitude of proteins involved in the DNA damage response and cell cycle checkpoints to maintain genomic integrity. BRCA1 functions by regulating the activities of its interacting proteins which mediate processes such as gene transcription, gene repression, protein phosphorylation, and ubiquitination.

Gene ID: 672

NCBI Accession: NP_009225

UniProt: P38398

Pathways: Cell Division Cycle, DNA Damage Repair, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus