ErbB2/Her2 antibody (C-Term)

Catalog No. ABIN7448962

This Rabbit Polyclonal antibody specifically detects ErbB2/Her2 in IHC and IF (p). It exhibits reactivity toward Human.

Quick Overview for ErbB2/Her2 antibody (C-Term) (ABIN7448962)

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ErbB2/Her2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-ErbB2/Her2 Antibody

Binding Specificity: C-Term

Purpose: Rabbit anti-ErbB2 IHC Antibody, Affinity Purified

Predicted Reactivity: Mouse,Rat,Dog,Horse,Rabbit,Pig,Golden hamster,Panda,Cat,Orangutan,Monkey,Gorilla,Chimpanzee,American black bear,White-tufted-ear marmoset,Small-eared galago,Naked mole rat,Chinese hamster,Crab-eating macaque,Thirteen-lined ground squirrel,Northern white-cheeked gibbon

Purification: Affinity Purified

Immunogen: Between AA 1200 and C-term

Isotype: IgG

Application Details

Application Notes:

IHC-IF: 1:50 - 1:500

IHC: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for ErbB2/Her2

Target: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Alternative Name: ErbB2

Background: Background: ErbB2 is a member of the receptor tyrosine kinase family of proteins. The four members of this family are ErbB1 (Epidermal growth factor receptor, EGFR/HER1), ErbB2 (HER2/Neu), ErbB3 (HER3), and ErbB4 (HER4). The ErbB receptor members are single-pass transmembrane proteins with an extracellular ligand-binding domain and a cytoplasmic tyrosine-kinase domain. The epidermal growth factor (EGF) and its related proteins serve as the ligands for the ErbB receptors. Upon binding, the receptors heterodimerize, autophosphorylate and make contact with adapter molecules to transmit cellular signals involved in cell proliferation, survival, and differentiation. The ErbB2 receptor is the only member that does not interact with a ligand, but instead functions as a heterodimeric partner to coordinate signals from other ligand bound ErbB receptors. Amplification and/or overexpression of ErbB2 have been reported in many cancers.

Gene ID: 2064

NCBI Accession: NP_004439

UniProt: P04626

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development