Merlin antibody (C-Term)

Catalog No. ABIN7448991

This anti-Merlin antibody is a Rabbit Polyclonal antibody detecting Merlin in IHC and IF (p). Suitable for Human.

Quick Overview for Merlin antibody (C-Term) (ABIN7448991)

Target: Merlin (NF2) (Neurofibromin 2 (NF2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Merlin antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-Merlin Antibody

Binding Specificity: C-Term

Purpose: Rabbit anti-NF2 IHC Antibody, Affinity Purified

Predicted Reactivity: Mouse,Rat,Bovine,Dog,Horse,Rabbit,Pig,Panda,Orangutan,Gorilla,Chinese hamster,White-tufted-ear marmoset,Olive baboon,African elephant,Northern white-cheeked gibbon,Ferret,Naked mole rat,Thirteen-lined ground squirrel

Purification: Affinity Purified

Immunogen: Between AA 550 and C-term

Isotype: IgG

Application Details

Application Notes:

IHC-IF: 1:50 - 1:500

IHC: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 100 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for Merlin

Target: Merlin (NF2) (Neurofibromin 2 (NF2))

Alternative Name: NF2

Background: Background: Mutations in NF2 (neurofibromin 2) are associated with neurofibromatosis type II which is characterized by Schwann cell tumors (schwannomas) which are benign slow-growing tumors that are resistant to chemotherapeutic intervention. NF2 is a membrane/cytoskeletal associated protein that has been classified as a novel type of tumor suppressor due to its function in membrane organization versus a classic tumor suppressor function that regulates cell cycle machinery.

Gene ID: 4771

NCBI Accession: NP_000259

UniProt: P35240

Pathways: Cell-Cell Junction Organization