WDR77 antibody (AA 292-342)

Catalog No. ABIN7449034

This Rabbit Polyclonal antibody specifically detects WDR77 in IHC and IF (p). It exhibits reactivity toward Human and Mouse.

Quick Overview for WDR77 antibody (AA 292-342) (ABIN7449034)

Target: WDR77 (WD Repeat Domain 77 (WDR77))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WDR77 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-WDR77 Antibody

Binding Specificity: AA 292-342

Purpose: Rabbit anti-WDR77/MEP50 IHC Antibody, Affinity Purified

Predicted Reactivity: Orangutan,Monkey,Chimpanzee,Northern white-cheeked gibbon

Purification: Affinity Purified

Immunogen: Between AA 292 and 342

Isotype: IgG

Application Details

Application Notes:

IHC-IF: 1:50 - 1:500

IHC: 1:100 - 1:500

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for WDR77

Target: WDR77 (WD Repeat Domain 77 (WDR77))

Alternative Name: WDR77/MEP50

Background: Background: WDR77/MEP50 is a component of the methylosome, a large protein arginine methyltransferase complex that modifies specific arginines to dimethylarginines in splicesomal Sm proteins. WDR77/MEP50 associates with the methyltransferase JBP1 (PRMT5) and is important for methylosome activity. WDR77/MEP50 has also been shown to associate with the polycomb group protein, SUZ12, and histone H2A. In this context, WDR77/MEP50 is proposed to function as an adaptor between PRMT5 and its substrate H2A to regulate transcription.

Gene ID: 79084

NCBI Accession: NP_077007

UniProt: Q9BQA1

Pathways: Ribonucleoprotein Complex Subunit Organization