Recombinant Poliovirus Receptor antibody (AA 28-329)

Catalog No. ABIN7449549

This anti-Poliovirus Receptor antibody is a Rabbit Monoclonal antibody detecting Poliovirus Receptor in WB, IHC, FACS, ICC and IF (p). Suitable for Human.

Quick Overview for Recombinant Poliovirus Receptor antibody (AA 28-329) (ABIN7449549)

Target: Poliovirus Receptor (PVR)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Poliovirus Receptor antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Clone: BLR074G

Product Details anti-Poliovirus Receptor Antibody

Binding Specificity: AA 28-329

Purpose: Rabbit anti-PVR/CD155 Recombinant Monoclonal Antibody [BLR074G]

Immunogen: residues 28-329 (ECD)

Isotype: IgG

Application Details

Application Notes:

IHC-IF: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IHC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

ICC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.

WB: 01:01,00

Restrictions: For Research Use only

Handling

Concentration: 100 μg/mL

Buffer: Borate Buffered Saline (BBS) pH 8.2 with 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for Poliovirus Receptor

Target: Poliovirus Receptor (PVR)

Alternative Name: PVR/CD155

Background: Background: PVR/CD155 is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. It mediates NK cell adhesion and triggers NK cell effector functions. PVR/CD155 binds two different NK cell receptors: CD96 and CD226, and these interactions accumulate at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. PVR/Cd155 also promotes NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. PVR/CD155 also plays a role in mediating tumor cell invasion and migration. [taken from the Universal Protein Resource (UniProt) P15151]. "

Gene ID: 5817

NCBI Accession: NP_006496

UniProt: P15151

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Cancer Immune Checkpoints, SARS-CoV-2 Protein Interactome