RENT1/UPF1 antibody (AA 1079-1129)

Catalog No. ABIN7450651

This Rabbit Polyclonal antibody specifically detects RENT1/UPF1 in WB and IP. It exhibits reactivity toward Human and Mouse.

Quick Overview for RENT1/UPF1 antibody (AA 1079-1129) (ABIN7450651)

Target: RENT1/UPF1 (UPF1) (UPF1 Regulator of Nonsense Transcripts Homolog (UPF1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RENT1/UPF1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-RENT1/UPF1 Antibody

Binding Specificity: AA 1079-1129

Purpose: Rabbit anti-RENT1 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 1079 and 1129

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for RENT1/UPF1

Target: RENT1/UPF1 (UPF1) (UPF1 Regulator of Nonsense Transcripts Homolog (UPF1))

Alternative Name: RENT1

Background: Background: RENT1, also known as UPF1, is a key regulator of the nonsense-mediated mRNA decay (NMD) pathway. The NMD pathway eliminates mRNAs that prematurely terminate during translation and may serve to protect the cells from dominant-negative effects of truncated proteins, or as a means to regulate protein expression. RENT1 is an ATP-dependent 5'- 3' RNA helicase and ATPase that localizes to the cytoplasm and is part of a post-splicing multiprotein complex as well as an mRNA decay complex.

Gene ID: 5976

NCBI Accession: NP_002902

UniProt: Q92900

Pathways: SARS-CoV-2 Protein Interactome