MPRIP antibody (AA 400-450)

Catalog No. ABIN7450660

This Rabbit Polyclonal antibody specifically detects MPRIP in WB and IP. It exhibits reactivity toward Human.

Quick Overview for MPRIP antibody (AA 400-450) (ABIN7450660)

Target: MPRIP (Myosin Phosphatase rho Interacting Protein (MPRIP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MPRIP antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-MPRIP Antibody

Binding Specificity: AA 400-450

Purpose: Rabbit anti-RIP3 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: Between AA 400 and 450

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for MPRIP

Target: MPRIP (Myosin Phosphatase rho Interacting Protein (MPRIP))

Alternative Name: RIP3

Background: Background: Receptor-interacting serine/threonine-protein kinase 3 (RIP3) is essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIP3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIP3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production [taken from the Universal Protein Resource (UniProt) Q9Y572].

Gene ID: 11035

NCBI Accession: NP_006862

UniProt: Q9Y572