Nicastrin antibody (AA 659-709)

Catalog No. ABIN7451011

This Rabbit Polyclonal antibody specifically detects Nicastrin in WB and IP. It exhibits reactivity toward Human.

Quick Overview for Nicastrin antibody (AA 659-709) (ABIN7451011)

Target: Nicastrin (NCSTN)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Nicastrin antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-Nicastrin Antibody

Binding Specificity: AA 659-709

Purpose: Rabbit anti-Nicastrin Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: Between AA 659 and 709

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: 1:500 - 1:2,500

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for Nicastrin

Target: Nicastrin (NCSTN)

Alternative Name: Nicastrin

Background: Background: Nicastrin is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex [taken from the Universal Protein Resource (UniProt) Q92542].

Gene ID: 23385

NCBI Accession: NP_056146

UniProt: Q92542

Pathways: Notch Signaling, Neurotrophin Signaling Pathway