PITRM1 antibody (AA 987-1037)

Catalog No. ABIN7451174

The Rabbit Polyclonal anti-PITRM1 antibody has been validated for IP. It is suitable to detect PITRM1 in samples from Human.

Quick Overview for PITRM1 antibody (AA 987-1037) (ABIN7451174)

Target: PITRM1 (Pitrilysin Metallopeptidase 1 (PITRM1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PITRM1 antibody is un-conjugated

Application: Immunoprecipitation (IP)

Product Details anti-PITRM1 Antibody

Binding Specificity: AA 987-1037

Purpose: Rabbit anti-PITRM1 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: Between AA 987 and 1037

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: Not recommended. ABIN7451174 has not performed satisfactorily when used for WB of PITRM1 in crude preparations (e.g. whole cell lysate). This antibody can be used for WB of enriched (e.g. immunoprecipitated) sources of PITRM1.

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for PITRM1

Target: PITRM1 (Pitrilysin Metallopeptidase 1 (PITRM1))

Alternative Name: PITRM1

Background: Background: Pitrilysin metalloproteinase 1 (PITRM1) is an ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. PITRM1 also degrades other unstructured peptides. It is specific for peptides in the range of 10 to 65 residues. It is able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. PTMRM shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference [taken from the Universal Protein Resource (UniProt) Q5JRX3].

Gene ID: 10531

UniProt: Q5JRX3

Pathways: PI3K-Akt Signaling, SARS-CoV-2 Protein Interactome