CSK antibody (AA 375-425)

Catalog No. ABIN7451223

This anti-CSK antibody is a Rabbit Polyclonal antibody detecting CSK in IP. Suitable for Human.

Quick Overview for CSK antibody (AA 375-425) (ABIN7451223)

Target: CSK (C-Src tyrosine Kinase (CSK))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CSK antibody is un-conjugated

Application: Immunoprecipitation (IP)

Product Details anti-CSK Antibody

Binding Specificity: AA 375-425

Purpose: Rabbit anti-CSK Antibody, Affinity Purified

Predicted Reactivity: Mouse,Rat,Chicken,Bovine

Purification: Affinity Purified

Immunogen: Between AA 375 and 425

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: Not recommended. Use rabbit anti-CSK antibody ABIN7450141.

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for CSK

Target: CSK (C-Src tyrosine Kinase (CSK))

Alternative Name: CSK

Background: Background: C-Src kinase (CSK) is a non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. CSK phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. CSK suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK [taken from the Universal Protein Resource (UniProt) P41240].

Gene ID: 1445

NCBI Accession: NP_004374

UniProt: P41240

Pathways: TCR Signaling, EGFR Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events