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CHEK2 antibody (AA 1-50)

This anti-CHEK2 antibody is a Rabbit Polyclonal antibody detecting CHEK2 in WB and IP. Suitable for Human.
Catalog No. ABIN7451703

Quick Overview for CHEK2 antibody (AA 1-50) (ABIN7451703)

Target

See all CHEK2 Antibodies
CHEK2 (Checkpoint Kinase 2 (CHEK2))

Reactivity

  • 238
  • 86
  • 72
  • 16
  • 13
  • 7
  • 6
  • 5
  • 4
  • 2
  • 2
  • 1
Human

Host

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  • 1
Rabbit

Clonality

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  • 35
Polyclonal

Conjugate

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  • 9
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  • 7
  • 7
  • 7
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  • 7
  • 7
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
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  • 2
  • 1
This CHEK2 antibody is un-conjugated

Application

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  • 79
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  • 28
  • 24
  • 21
  • 18
  • 5
  • 1
  • 1
  • 1
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  • 1
Western Blotting (WB), Immunoprecipitation (IP)
  • Binding Specificity

    • 26
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    • 17
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    • 9
    • 8
    • 8
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    • 1
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    • 1
    • 1
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    AA 1-50

    Purpose

    Rabbit anti-Chk2 Antibody, Affinity Purified

    Purification

    Affinity Purified

    Immunogen

    between AA 1 and 50

    Isotype

    IgG
  • Application Notes

    IP: 2 - 5 μg/mg lysate

    WB: 1:2,000 - 1:10,000

    Restrictions

    For Research Use only
  • Concentration

    1000 μg/mL

    Buffer

    Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C

    Expiry Date

    12 months
  • Target

    CHEK2 (Checkpoint Kinase 2 (CHEK2))

    Alternative Name

    Chk2

    Background

    Background: Chk2 functions as a checkpoint protein kinase in response to DNA damage to maintain genomic stability. The yeast homologs are RAD53 and Cds1. The two major upstream controllers of Chk2 are ATM and ATR which are part of the phosphatidylinositol 3-kinase family. When activated, Chk2 targets p53, Brca1, Cdc25A and Cdc25C to cause cell cycle arrest. Chk2 is also known as serine/threonine-protein kinase CHK2, CHEK2, CDS1, LFS2, RAD53, HuCds1, and PP1425.

    Gene ID

    11200

    NCBI Accession

    NP_009125

    UniProt

    O96017

    Pathways

    p53 Signaling, Apoptosis, Cell Division Cycle
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