Huntingtin antibody (AA 1150-1200)

Catalog No. ABIN7451812

This Rabbit Polyclonal antibody specifically detects Huntingtin in WB and IP. It exhibits reactivity toward Human.

Quick Overview for Huntingtin antibody (AA 1150-1200) (ABIN7451812)

Target: Huntingtin (HTT)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Huntingtin antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-Huntingtin Antibody

Binding Specificity: AA 1150-1200

Purpose: Rabbit anti-Huntingtin Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 1150 and 1200

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for Huntingtin

Target: Huntingtin (HTT)

Alternative Name: Huntingtin

Background: Background: The Huntingtin (HTT) gene is linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range in the number of trinucleotide repeats has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene product is widely expressed and is required for normal development [taken from NCBI Entrez Gene (Gene ID: 3064)].

Gene ID: 3064

NCBI Accession: NP_002102

UniProt: P42858

Pathways: PI3K-Akt Signaling, Hormone Transport, Transition Metal Ion Homeostasis, Tube Formation, Protein targeting to Nucleus, Dicarboxylic Acid Transport