PRCC antibody (AA 425-475)

Catalog No. ABIN7451980

Product Details anti-PRCC Antibody

Target: PRCC (Papillary Renal Cell Carcinoma (Translocation-Associated) (PRCC))

Binding Specificity: AA 425-475

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PRCC antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Purpose: Rabbit anti-PRCC Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 425 and 475

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for PRCC

Target: PRCC (Papillary Renal Cell Carcinoma (Translocation-Associated) (PRCC))

Alternative Name: PRCC (PRCC Products)

Synonyms: tprc antibody, XPrcc antibody, rccp1 antibody, RCCP1 antibody, TPRC antibody, papillary renal cell carcinoma (translocation-associated) antibody, PRCC antibody, prcc antibody, Prcc antibody

Background: Background: In a subset of papillary renal cell carcinomas, a t(X,1)(p11,q21) chromosome translocation has been repeatedly reported and is thought to be the cause of the cancer. As a result of the translocation, the transcription factor TFE3 on the X chromosome becomes fused to the PRCC (papillary renal cell carcinoma translocation-associated) gene on chromosome 1. The fused gene results in the fusion of N-terminal proline-rich region of the protein encoded by this gene to the entire TFE3 protein. This protein has been shown to interact with the mitotic checkpoint protein MAD2B, which suggests that the dominant-negative effect of the fusion protein with TFE3 may lead to a mitotic checkpoint defect [taken from NCBI GeneID:5546].

Gene ID: 5546

NCBI Accession: NP_005964

UniProt: Q92733