PRCC antibody (AA 125-175)
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- Target See all PRCC Antibodies
- PRCC (Papillary Renal Cell Carcinoma (Translocation-Associated) (PRCC))
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Binding Specificity
- AA 125-175
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PRCC antibody is un-conjugated
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Application
- Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))
- Purpose
- Rabbit anti-PRCC Antibody, Affinity Purified
- Purification
- Affinity Purified
- Immunogen
- between AA 125 and 175
- Isotype
- IgG
- Top Product
- Discover our top product PRCC Primary Antibody
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- Application Notes
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IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 2 - 5 μg/mg lysate
WB: Not recommended. Use rabbit anti-PRCC antibody A302-340A.
- Restrictions
- For Research Use only
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- Concentration
- 1000 μg/mL
- Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Expiry Date
- 12 months
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- Target
- PRCC (Papillary Renal Cell Carcinoma (Translocation-Associated) (PRCC))
- Alternative Name
- PRCC (PRCC Products)
- Synonyms
- tprc antibody, XPrcc antibody, rccp1 antibody, RCCP1 antibody, TPRC antibody, papillary renal cell carcinoma (translocation-associated) antibody, PRCC antibody, prcc antibody, Prcc antibody
- Background
- Background: In a subset of papillary renal cell carcinomas, a t(X,1)(p11,q21) chromosome translocation has been repeatedly reported and is thought to be the cause of the cancer. As a result of the translocation, the transcription factor TFE3 on the X chromosome becomes fused to the PRCC (papillary renal cell carcinoma translocation-associated) gene on chromosome 1. The fused gene results in the fusion of N-terminal proline-rich region of the protein encoded by this gene to the entire TFE3 protein. This protein has been shown to interact with the mitotic checkpoint protein MAD2B, which suggests that the dominant-negative effect of the fusion protein with TFE3 may lead to a mitotic checkpoint defect [taken from NCBI GeneID:5546].
- Gene ID
- 5546
- NCBI Accession
- NP_005964
- UniProt
- Q92733
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