Tuberin antibody (C-Term)

Catalog No. ABIN7452209

The Rabbit Polyclonal anti-Tuberin antibody has been validated for WB and IP. It is suitable to detect Tuberin in samples from Human.

Quick Overview for Tuberin antibody (C-Term) (ABIN7452209)

Target: Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Tuberin antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-Tuberin Antibody

Binding Specificity: C-Term

Purpose: Rabbit anti-TSC2 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogen: between AA 1750 and C-term

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 5 μg/mg lysate

WB: 1:5,000 - 1:15,000

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for Tuberin

Target: Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))

Alternative Name: TSC2

Background: Background: Tuberous sclerosis 2 protein (TSC2) forms a heterodimer with TSC1 to integrate cellular growth and stress signals. Defects in the TSC1 and TSC2 gene are responsible for the genetic disorder tuberous sclerosis. The TSC1/TSC2 complex functions in the mTOR pathway by negatively regulating mTOR activity via the small GTP-binding protein Rheb. TSC2 also been shown to interact with FOXO1 transcription factor.

Gene ID: 7249

NCBI Accession: NP_000539

UniProt: P49815

Pathways: RTK Signaling, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus